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T16833 |
S1P1 Agonist III
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Others
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S1P1 Agonist III is an effective and orally active S1P1 agonist (EC50: 18 nM). |
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T62732 |
S1P1 agonist 5
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S1P1 agonist 5 is a selective, orally active S1P1 agonist. S1P1 agonist 5 inhibits the drainage of lymphocytes from lymphoid tissue into peripheral blood. S1P1 agonist 5 has potential for studies in multiple sclerosis (M... |
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T79816 |
S1P1 agonist 6
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LPL Receptor
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Compound I (S1P1 agonist 6) is an S1P1 agonist that mitigates autoimmune activity by inhibiting lymphocyte trafficking and has potential as an immunosuppressive agent in autoimmune disease research [1]. |
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T61639 |
S1P1 agonist 4
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S1P1 agonist 4 exhibits enhanced potency with an EC 50 value of less than 0.05 mg/kg and a predicted human half-life (t1/2) of approximately 5 days, indicating a favorable pharmacological profile. |
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T79817 |
S1P1 agonist 6 hemicalcium
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LPL Receptor
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Compound I (S1P1 agonist 6 hemicalcium) is an S1P1 agonist that diminishes autoimmune activity by inhibiting lymphocyte trafficking, and serves as an immunosuppressive agent in researching a range of autoimmune diseases ... |
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T38716 |
SAR247799
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SAR247799,S1P1 agonist 3 |
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SAR247799 (S1P1 agonist 3) is an orally-active, selective G-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (S1P1). It demonstrates EC50 values ranging from 12.6 to 493 nM in S1P1-overexpressing cells a... |
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T6403 |
Siponimod
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BAF-312 |
S1P Receptor
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LPL Receptor
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BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. The specificity of BAF312 for S1P1 and S1P5 receptors exhibi... |
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T7360 |
GSK2018682
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S1P Receptor
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LPL Receptor
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GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). |
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T15031 |
CYM50260
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Others
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LPL Receptor
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CYM50260 is a potent and exquisitely selective agonist of sphingosine-1-phosphate 4 receptor (S1P4-R, EC50= nM) with no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R. |
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T3258 |
Ponesimod
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ACT-128800 |
S1P Receptor
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LPL Receptor
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Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity. |
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T2171 |
SEW2871
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SEW2871 |
S1P Receptor
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LPL Receptor
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SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, an... |
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T10385 |
ASP-4058
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S1P Receptor
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LPL Receptor
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ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experimental autoimmune encephalomyelitis in mice. |
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T14924 |
Cenerimod
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ACT-334441 |
S1P Receptor
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Cenerimod (ACT-334441) is an orally active, selective, and potent sphingosine 1-phosphate receptor (S1P1) agonist (EC50: 1 nM).Cenerimod inhibits multiple S1P isoforms and can be used to study murine experimental autoimm... |
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T22697 |
CS 2100
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1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid |
S1P Receptor
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CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist. |
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T4031 |
S1p receptor agonist 1
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S1p-receptor-agonist-1 |
S1P Receptor
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LPL Receptor
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S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist. |
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T15032 |
CYM50308
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S1P Receptor
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LPL Receptor
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CYM50308 is a high affinity agonist of sphingosine-1-phosphate receptor 4 (S1P4-R) (EC50: 56 nM). CYM50308 has no activity at S1P1-R, S1P2-R and S1P3-R subtypes at concentrations up to 25 μM and it shows 37-fold more sel... |
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T2026 |
CYM5442
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S1P Receptor
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LPL Receptor
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CYM5442 is an S1P agonist, targeting to Sphingosine. |
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T28385 |
PF-462991
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PF-991,PF991,PF 991,PF 462991 |
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PF-462991 is a S1P1 agonist. |
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T26557 |
ACT-209905
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ACT 209905,ACT209905 |
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ACT-209905 is an agonist of S1P1 receptor. |
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T27459 |
GSK2263167
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GSK-2263167,GSK 2263167 |
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GSK2263167 is an agonist of S1P1 receptor. |
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T32005 |
GSK1842799
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GSK 1842799 |
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GSK1842799 is a selective S1P1 receptor agonist with good oral bioavailability. |
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T68678 |
VPC 24191
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VPC 24191 is a sphingosine 1-phosphate (S1P1/3) receptor agonist. |
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T31107 |
CS-0777
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CS0777,CS 0777 |
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CS-0777 is a potent, selective, and orally active S1P1 agonist (sphingosine 1-phosphate receptor modulator). |
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T71564 |
GSK2018682 HCl
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GSK2018682 is a novel sphingosine-1-phosphate receptor 1 (s1p1) and 5 (s1p5) agonist. |
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T32006 |
GSK-2262167 sodium
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GSK-2262167,GSK2262167,GSK 2262167 |
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GSK-2262167 is a potent S1P1 agonist, as effective as fingolimod in collagen-induced arthritis models, and shows good preclinical pharmacokinetic properties. |
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T71392 |
(R)-FTY-720 Vinylphosphonate
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(R)-FTY-720 Vinylphosphonate is a sphingosine 1-phosphate type 1 (S1P1) receptor agonist and lacks anti-apoptotic activity. |
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T29971 |
AMG-369
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KB74649,KB 74649,AMG369,KB-74649 |
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AMG-369 (KB74649) is an effective S1P1/S1P5 dual agonist, with limited activity in S1P3, but no activity in S1P2/S1P4. |
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T71069 |
GSK1842799 HCl
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GSK1842799 is a selective S1P1 receptor agonist for multiple sclerosis. Upon phosphorylation, GSK1842799 showed subnanomole S1P1 agonist activity with >1000× selectivity over S1P3. GSK1842799 demonstrated good oral bioa... |
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T12780L |
RP-001 hydrochloride
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Others
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RP-001 hydrochloride is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5. |
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T12780 |
RP-001
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Others
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RP-001 is a selective agonist of picomolar short-acting S1P1 (EDG1)(EC50 of 9 pM), has little activity on S1P2-S1P4 and only moderate affinity for S1P5. |
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T30529 |
BMS-520
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BMS-520 is a potent, selective S1P1 agonist that has shown impressive efficacy when administered orally in a rat model of arthritis and in a mouse model of experimental autoimmune encephalomyelitis (EAE) with multiple sc... |
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T17237 |
VPC 23019
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S1P Receptor
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LPL Receptor
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VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively). |
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T62517 |
S1p receptor agonist 2
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S1p receptor agonist 2 (compound 1) is an agonist of the S1P5 receptor with a higher selectivity than S1P1 and/or S1P3 receptors.S1p receptor agonist 2 can be used in the endogenous SIP signaling system and in the mitiga... |
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T21916 |
TC-SP 14
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TC-SP 14, also known as compound 14, is a highly active and potent S1P1 agonist with oral bioavailability. It exhibits an EC50 value of 0.042 μM, indicating its strong binding affinity to the S1P1 receptor. Notably, its ... |
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T61621 |
IMMH001
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IMMH001, also known as SYL930, is an orally active compound that exhibits potent selectivity as an agonist for the S1P1 receptor, which is the sphingosine-1-phosphate receptor 1. This compound effectively reduces the lev... |
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T37548 |
Azido-FTY720
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azido-FTY720 |
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FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survi... |
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T63141 |
ASP-4058 hydrochloride
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ASP-4058 hydrochloride is a selective, orally active secondary agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5). ASP-4058 hydrochloride is safe and improves experimental autoimmune encephalomyelitis in ... |
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T37187 |
D-erythro/L-threo Lysosphingomyelin (d18:1)
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D-erythro/L-threo Lysosphingomyelin (d18:1) |
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Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis... |
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T37791 |
A-971432
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A-971432 is a sphingosine-1-phosphate receptor 5 (S1P5) agonist that is selective for S1P5 over S1P1 and S1P3 (IC50s = 0.006, 0.362, and >10 µM, respectively). It inhibits forskolin-induced cAMP production in CHO cel... |
